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Cleft lip and palate can typically be identified via ultrasound around 16 weeks of pregnancy, with confirmation possible through high-level ultrasound between 20-22 weeks. If confirmed, pregnant individuals should consider amniocentesis and amniotic fluid microarray analysis to check for chromosomal abnormalities. Amniocentesis detects major chromosomal issues, while microarray analysis examines smaller genetic deletions in greater detail.
If cleft lip and palate is detected after 24 weeks, amniocentesis remains advisable. Even if non-invasive prenatal testing at 10 weeks shows normal results, abnormalities on ultrasound, such as cleft lip and palate, warrant amniocentesis.
If chromosomal abnormalities accompany cleft lip and palate, consultation with a healthcare provider is recommended to discuss associated conditions and pregnancy continuation. In cases without chromosomal issues, surgical techniques for cleft lip and palate can result in outcomes comparable to those of unaffected children.
Most cases of cleft lip and palate relate to embryonic development rather than genetic factors, so understanding the medical and pregnancy history is important. Avoid letting traditional beliefs influence decisions.
For newborns with cleft lip and palate, brain ultrasound, heart ultrasound, and abdominal ultrasound are advised to assess for structural issues.
Babies with isolated cleft palate may have incomplete midline fusion during development, necessitating brain, heart, and abdominal ultrasounds in the newborn period.
If cleft palate occurs with retrognathia and glossoptosis, it could indicate Pierre Robin syndrome. Monitor for smooth breathing, signs of sternal retraction, and laryngomalacia, as pediatricians will check for these.
In rare instances of larger combined abnormalities, chromosomal or genetic testing may be added, along with endocrine screenings like thyroid and parathyroid function tests, and hearing evaluations. Healthcare providers will tailor checks to the baby's specific condition.